He was the third bishop, (the first ethnically-Chinese one), of the Roman Catholic Diocese of Hong Kong.

Born into a Methodist family in Shanghai, Hsu joined the Catholic Church when he was teaching at a National Central University in Nanking between 1944 and 1947.

[2] Hsu escaped to Hong Kong in 1950 after the Kuomintang left mainland China.

Hsu was the editor of Kung Kao Po, a Catholic newspaper in Hong Kong, from 1959 to 1965.

Francis Hsu died in Hong Kong on 23 May 1973 from a heart attack.