Francis Miller Fesmire (November 16, 1959 – January 31, 2014) was an American emergency physician and a nationally recognized expert in myocardial infarction.

[19] The culmination of his studies was The Erlanger Chest Pain Evaluation Protocol published in the Annals of Emergency Medicine in 2002.

[22] His most recent research involved the risk stratification of chest pain patients in the emergency department.

Fesmire received the Emergency Medicine Foundation's Young Investigator Award in 1996 for his work in developing a rapid protocol for the evaluation of chest pain patients.

[26] In 2006, he received the Ig Nobel Prize in Medicine for a 1988 case report detailing the use of digital rectal massage as a cure for persistent singultus (hiccups).