[2][3] At the prompting of his uncle, Monsignor Jakob Missia, he studied at the Jesuits' Kalksburg College on the outskirts of Vienna.

With this connection, Francis Missia went to the United States in August 1903 to attend the Saint Paul Seminary, knowing no English at the time.

[6] When Archbishop John Gregory Murray established a Sacred Music Commission in 1932, he placed Father Missia in charge.

[2][6] Missia directed number recordings of the Saint Paul Seminary choir released through Kay Bank Studios.

To this day, a piece he arranged, Tu Es Sacerdos in Aeternum (composed by Vojtěch Říhovský), is still used at ordinations for the diocese.