Francis Parker House, also known as Parker's Big Run or High House, is a historic home located near Murfreesboro, North Carolina and Northampton County, North Carolina.

It was built about 1785, and is a 1+1⁄2-story, hall and parlor plan, Georgian style frame dwelling with a one-story rear wing.

It has a gambrel roof, is sheathed in weatherboard, sits on a raised brick basement, and rebuilt massive paved double-shoulder exterior end chimneys.

The contributing Vaughan house and pyramidal-roof frame dairy (formerly located in Hertford County near the Parker house), were also moved to the site.

This article about a property in Northampton County, North Carolina on the National Register of Historic Places is a stub.