The son of Francis Prujean, rector of Boothby, Lincolnshire,[a] he was born at Bury St Edmunds, and educated by his father.
He was registrar from 1641 to 1647, and president from 1650 to 1654, in the last of which years he was chosen, on the recommendation of William Harvey who declined the post.
When Queen Catherine of Braganza had typhus fever in October 1663, he attended her, and her recovery was attributed to a cordial he prescribed.
John Evelyn described his laboratory and collection of pictures, and mentions that he played on the "polythore", a musical instrument combining features of the harp, lute and theorbo.
Rochester Carre of Lincolnshire, the younger brother of Sir Robert Carre baronet of Aswarby, who was declared a lunatic in 1637, lived with him under treatment for upwards of twenty years and he also dealt with Sir Robert himself when his mental state was questioned by Parliament in 1646.
[1] Samuel Pepys called him a man of great judgment but who sadly left no written works behind him.