[9] In 1987, at age 16, he graduated from St. Mary's Catholic High School, Dubai, UAE[10] and was admitted to the Massachusetts Institute of Technology (MIT).

[15][non-primary source needed] In 1997 DeSouza co-founded and was CEO of Flash Communications, a provider of corporate instant messaging that was acquired by Microsoft in 1998.

[17] DeSouza left Microsoft in 2001 and founded IMlogic, where he was CEO[18] and grew the company into the market leading provider of instant messaging security.

[21][22] He led the research, product management, engineering, customer support and operations for Symantec's offerings, which generated $6.73 billion in revenue in FY11.

[26] DeSouza co-founded SynthLabs in July 2023, a startup developing technology for an auditable, transparent and robust AI alignment platform.