Francisca Lewin was born in Santiago in 1980, the daughter of Ángela Castellano, a professor at the Pontifical Catholic University's School of Nursing.

[1] She studied acting at the Theater School of the Pontifical Catholic University, graduating in October 2002, with the production Hombre pobre todo es trazas by Pedro Calderón de la Barca.

Corazón de María [es] is a telenovela in which Lewin plays a young transplanted woman, Elisa, who has a complicated family history.

In the same year, Francisca starred with Álvaro Rudolphy in the nightly television series Conde Vrolok, playing Emilia Verdugo.

In 2011, she dedicated herself fully to theater in the Guillermo Calderón play Villa+Discurso, and in 2012 she appeared in the feature film Educación física with Pablo Cerda [es].

She played Carolina Salazar, the innocent young woman who arrives in Las Condes to work as a personal assistant to the voracious and ruthless owner of a fashion store.

In 2007, she was hired by Ingesa S.A. to be the face of Skechers sneakers, a position previously held by actress Carolina Varleta [es].