Francisco Antonio Pérez Salas (1764 – November 10, 1828) was a Chilean political figure.

He served several times as member of different Government Juntas, and participated actively in the war of independence in that country.

He was born in Santiago, the son of José Pérez García and of Ana Josefa Ramirez de Salas y Pavón.

He was a member of the Government Junta established on April 13, 1813, together with Agustín Eyzaguirre and José Miguel Infante.

During the period of the Spanish Reconquista, he was arrested and imprisoned in Juan Fernández island.