Francisco Antonio de Acuña Cabrera y Bayona (Spain; 1597 – Lima; 1662) was a Spanish soldier and governor of the Captaincy General of Chile between 1650 and 1656.
After serving in Flanders and France, he went to Peru as Maestre de Campo of El Callao and a general, being designated later Royal Governor of Chile.
An ambitious man and badly advised by his relatives and friends, his government was characterised by continuous difficulties with the natives and the vecinos of Concepción.
The failure of the 1554 expedition at the Battle of Río Bueno and the indigenous revolt of 1655, motivated the vecinos of Concepcion to declare the deposition of Acuña to the shouts of ' The king lives!
A new governor Pedro Porter Casanate, was appointed, and his first mission was to force the return of Acuña to Lima, where he would die shortly afterwards.