Paco Bru began his career in the spring of 1902 with FC Internacional —when he was only sixteen years — playing a friendly tournament called Medalla de la Federación Gimnástica Española (Medal of the Spanish Gymnastics Federation).

On 30 November 1902, Bru made his debut in official competition, the Catalan football championship, in a 6–0 defeat to Club Español.

Two years later he joined FC Barcelona and, along with Romà Forns, helped the club win the Campionat de Catalunya three times in a row between 1909 and 1911.

He then returned to FC Barcelona and, together with Paulino Alcántara and Jack Greenwell, helped the club win one more Campionat.

In 1920 when the Royal Spanish Football Federation decided to send a team to the Olympic Games, Bru was one of three selectors chosen to pick the squad.

With a squad that included Ricardo Zamora, Félix Sesúmaga, Pichichi, José María Belauste and Josep Samitier, Bru and Spain returned from the competition with the silver medal.

Belgium won the gold medal by default after Czechoslovakia walked off in protest during the final, unhappy with the performance of the referee.

During the Spanish Civil War, Bru returned to Catalonia and coached Girona FC in the Mediterranean League.