Francisco Castellón Sanabria (1815 – 8 September 1855) was president of "Democratic" Nicaragua from 1854 to 1855 during the Granada-León civil war.
He was prime minister (ministro general) under Patricio Rivas, but was removed in 1841 by Pablo Buitrago, and reappointed in 1843 by Manuel Pérez.
The rigged election and Chamorro's subsequent actions including the promulgation of the Constitution of 1854, considered to be badly flawed by the Liberals, provoked prominent Liberals - including Francisco Castellón, Máximo Jerez, and José María Valle - to establish a separate government which they did in León.
Although his forces were initially militarily successful against Chamorro, a long unsuccessful siege of Granada was followed by the loss of Managua, Masaya and Rivas.
Castellón died of cholera 8 September 1855 and was succeeded as "Democratic" president by Nazario Escoto.