Francisco Polti Santillán (November 17, 1938) is a prelate of the Roman Catholic Church.
Born in Santiago del Estero, Polti Santillán became a member of Opus Dei.
On July 13, 1994, he was appointed bishop of Santo Tomé.
Polti Santillán received his episcopal consecration on the following August 22 from Antonio Quarracino, archbishop of Buenos Aires, with archbishop of Santa Fe de la Vera Cruz, Edgardo Gabriel Storni, archbishop emeritus of Corrientes, Fortunato Antonio Rossi, archbishop of Corrientes, Domingo Salvador Castagna, and bishop of Posadas, Alfonso Delgado Evers, serving as co-consecrators.
On May 17, 2006, he was appointed bishop of Santiago del Estero, where he was installed on the following July 22.