Francisco Ramírez Medina [note 1] (born c.1828), was one of the leaders of "El Grito de Lares", the first major revolt against Spanish rule and call for independence in Puerto Rico in 1868.

History has little to say about Ramírez Medina and his personal life; what is known however, is that he was a believer in the Puerto Rican independence movement.

[1] However, it wasn't until 1868 when a revolt was initially started and planned by Ramón Emeterio Betances and Segundo Ruiz Belvis against the Government of Spain which then ruled the island.

Manuel Rojas, Mariana Bracetti and Mathias Brugman joined them by forming revolutionary cells in the island.

Castañón and his men then entered González's residence and confiscated the documents of Medina's meeting and alerted his commanding officer in Arecibo.

Some 400–600 rebels gathered on that day in the hacienda of Manuel Rojas, located in the vicinity of Peñuelas, on the outskirts of Lares.

[5] According to Puerto Rican poet Luis Lloréns Torres the white cross on it stand for the yearning for homeland redemption; the red squares, the blood poured by the heroes of the rebellion and the white star in the blue solitude square, stands for liberty and freedom.

The Spanish militia, however, surprised the group with strong resistance, causing great confusion among the armed rebels who, led by Manuel Rojas, retreated back to Lares.

In addition it makes recognition of Ramírez Medina with a character in the play entitled "El Grito de Lares ... un momento en la historia."