Francisco Rodríguez Murillo (born February 26, 1983) is a Mexican former professional baseball pitcher.

In 2006, he won the California League Pitcher of the Week honors while pitching for the High-A Rancho Cucamonga Quakes.

For the 2007 season, Rodríguez returned to Rancho Cucamonga and posted a 4-8 record and 5.96 ERA in 39 games with the team.

[1] On April 14, 2010, Rodríguez was selected to the 40-man roster and promoted to the major leagues for the first time after closer Brian Fuentes was placed on the disabled list.

[2] He made his major league debut the next day, pitching 1 scoreless inning against the New York Yankees.

In 2011, Rodríguez made 10 appearances for the Angels, posting a 4.61 ERA, but missed much of the year with right shoulder inflammation.

On December 9, 2019, Rodríguez was traded to the Rieleros de Aguascalientes, but was released prior to the season, which was later cancelled due to the COVID-19 pandemic,[8] on March 24, 2020.

[10] On June 20, 2021, Rodríguez signed with the Tecolotes de los Dos Laredos of the Mexican League.