Francisco Seeber (November 15, 1841 – December 13, 1913) was an Argentine military officer, businessman and Mayor of Buenos Aires.

He invested in the city's first large-scale department store, Bon Marché, and was appointed Mayor of Buenos Aires on May 10, 1889, by President Miguel Juárez Celman.

Another plan approved during his tenure ultimately became Nueve de Julio Avenue in the 1930s, and his administration also began or completed the creation or improvement of numerous city parks and recreational and cultural sites, among them the Buenos Aires Zoo and the National Historical Museum.

Following an 1897 stay in Europe to study the organization of the Quartermaster Corps, he toured South America for an appreciation of prevailing conditions, about which he wrote in his 1903 survey, Argentina, Brasil, Chile, Uruguay, Perú, Bolivia y Paraguay: estudios comparativos.

Seeber, who also wrote numerous articles on his military studies in Europe, was named head of the Quartermaster's Advisory Board in Argentina.