Francisco de Borja Téllez-Girón y Pimentel, 10th Duke de Osuna (6 October 1785 – 21 May 1820), Grandee of Spain, was a Spanish nobleman.

Francisco Téllez-Girón was the 7th son of Pedro Téllez-Girón, 9th Duke of Osuna (1756–1807).

In 1802, he married Countess Marie Françoise Philippine Beaufort-Spontin (1785–1830), daughter of Frederic Augustus Alexander, Duke of Beaufort-Spontin and his wife Leopoldina Álvarez de Toledo (1760–1792), who in turn was the daughter of Pedro de Alcántara Álvarez de Toledo y Silva, 12th Duke of the Infantado.

Their son, the 11th Duke, Pedro de Álcantara was born in 1810, but died in 1844 without issue.

This biography of a Spanish noble is a stub.