[3] He served with the 4th Air Naval Gunfire Liaison Company (ANGLICO) in the Marine Forces Reserve in West Palm Beach.

When Zapata was unable to seek re-election in 2010 due to term limits, Artiles once again ran in the 119th District, and this time, won the primary election unopposed.

He won the Republican primary unopposed, and faced only write-in opposition in the general election, resulting in a landslide victory to his second term in the legislature.

Following a unanimous vote in support of the bill, Artiles remarked, "At the end of the day, the state of Florida has acted before the federal government in protecting our children from contaminating their lungs with vaporizing devices and e-cigarettes.

He declared, "We currently have the tools in our toolbox to stop the red-light infractions from occurring, we do not need the red light cameras today in Florida.

"[6] In 2015, Artiles filed a bill titled "Single-Sex Public Facilities", along with fellow representatives Dennis K. Baxley, Daphne Campbell, Matt Gaetz, Mike Hill, George Moraitis, Ray Rodrigues, and R. Stone, proposing that public bathrooms be limited to people by biological sex.

[7] During this time Artiles was also alleged to have punched a student in the face while at a bar near the capitol building in Tallahassee, a few hours before the 2015 legislative session was to start.

[11] In the preliminary committee meetings before the 2017 Senate session began, Artiles proposed SJR 134, a bill that, effectively, would require Miami-Dade County to elect a county-wide sheriff.

[16] The next morning, before the Senate investigation had begun, Artiles resigned, calling his continued presence in government a distraction and apologizing again.

[17] In a special election held in September 2017 to fill the vacant seat, Artiles was succeeded as Senator by Democrat Annette Taddeo.

Since 2008, Artiles and his wife have run a charity organization called Angel Share that raises money for needy families in the Miami area.