Francis Bernard McClain (April 14, 1864 – October 11, 1925) was the 11th lieutenant governor of Pennsylvania from 1915 to 1919.

McClain was born in Lancaster, Pennsylvania, during the American Civil War.

He worked as a cattle dealer and was instrumental in the formation of the Lancaster Live-Stock Exchange and was elected the first president.

McClain married Ellen Bernardine O'Neill of Lancaster, Pennsylvania, on February 14, 1888 (Valentine's Day); they had one child, who died in infancy.

McClain died in Lancaster, Pennsylvania, after a long illness, on October 11, 1925, aged 61 years old.