He won the WBC heavyweight title from Oliver McCall at Wembley Stadium in 1995, in what was his fourth world championship challenge.

[3] In retirement Bruno remained a celebrity with the British public, and his mental health issues received much media attention.

He won the European heavyweight title with a KO over Sweden's Anders Eklund, KO'd former European champion and world title contender Lucien Rodriguez in one round, was taken the distance for the first time by the useful world rated Phil Brown, and beat fringe fighters Larry Frazier and Jeff Jordan.

[citation needed] Bruno once again got himself back into title contention with wins over former contender James Tillis and journeymen Reggie Gross and Chuck Gardner.

Bugner, although long past his peak, was coming off good wins over Greg Page, James Tillis and David Bey.

He defeated contender Carl Williams, and then journeymen such as Jose Ribalta, Pierre Coetzer, and Dutchman Jan Emmen.

[citation needed] In 1993 he had a third world title chance against Lennox Lewis, who was making the second defence of the belt (his first of three championship reigns).

The Lennox Lewis vs. Frank Bruno fight was the first time that two British boxers had fought for the world heavyweight title.

[citation needed] Bruno again regrouped, dispatching Jesse Ferguson in one round and fringe contenders Rodolfo Marin and Mike Evans equally easily.

His manager for all but his last five fights was Terry Lawless, who signed him as a professional shortly after he had become ABA heavyweight champion at the age of eighteen.

[citation needed] On 22 September 2003, Bruno was taken from his home near Brentwood in Essex by medical staff assisted by police officers, under the provisions of the Mental Health Act 1983.

[10] Bruno also spoke on his own personal experiences in the mental health system at a conference run by Hari Sewell, on 22 June 2009.

The couple, who first met five years previously at a health resort, began dating months after bumping into each other at a wine bar near his home.

On 10 October 2006, Bruno and Clydesdale were jointly awarded £50,000 damages for libel against The People newspaper and publishers MGN in respect of false claims made about their relationship.

[citation needed] In 1993, Bruno briefly appeared as a guest on CITV's Finders Keepers hosted by Neil Buchanan.

[citation needed] In 1995, the year of his world championship, he released a cover version of "Eye of the Tiger", the theme song of the movie Rocky III.

Bruno made brief guest appearances in episodes of the ITV comedy show, Harry Hill's TV Burp in February and October 2011.

[23][24] In 2020 amid the COVID-19 crisis, Frank Bruno joined a group of celebrities called The Celebs which included Kellie Shirley and X Factor winner Sam Bailey to raise money for both Alzheimer's Society and Action for Children.

[25][26] In 2024, Bruno joined fellow London boxers - Lennox Lewis, Nigel Benn and Chris Eubank for Four Kings mini documentary.