Nicknamed "The Wise Guy", Buglioni made his professional debut in November 2011, stopping Sabie Montieth in the first round.

He won his first 10 fights before stopping Stepan Horvath in the eighth round in November 2013 to win the WBO European super middleweight title.

[2] He successfully defended the title three months later against Gaetano Nespro, but lost it in April 2014 when he was stopped by Sergey Khomitsky.

[2] Three months later he stopped Sam Couzens in four rounds to win the vacant BBBofC Southern Area super middleweight title.

[2] In November he regained the WBO European title with a unanimous decision over the previously unbeaten Andrew Robinson.

[2] He made two further defences (a first round stoppage of Ivan Jukic and a draw with Lee Markham) before beating Fernando Castaneda in July 2015 to take the vacant WBA International super middleweight title.

[9][10] On 10 December 2016, on the undercard of Anthony Joshua vs. Éric Molina, Buglioni fought Hosea Burton in a tightly contested 12 round affair.

[15] On 24 March 2018, Buglioni and Callum Johnson finally squared of in the ring, in a bid for both the British and the Commonwealth light heavyweight titles.

After achieving his International Baccalaureate Diploma from Highlands School, Buglioni attended the University of Westminster to study building surveying.