Cayou was a member of the Omaha tribe[3] and attended the Carlisle Indian Industrial School and then Dickinson College.

After the close of Carlisle's 1898 season, Cayou and Eddie Rogers played for Dickinson College, where they were enrolled in law school, in their Thanksgiving Day loss versus Penn State.

[4] He also played quarterback and running back for Illinois Fighting Illini[5] and was noted for his speed that was displayed on a 95-yard kickoff return versus Purdue.

[11] Cayou was the 16th head football coach at Wabash College, serving from 1904 to 1907, and compiling a record of 20–12–1.

In 1905, Cayou led Wabash to one of its most impressive upsets when it defeated Notre Dame, 5–0, at South Bend.