Following his marriage in 1894 to Amy Loosley, the couple moved to Peoria, Illinois, where Frank practiced for four years there before returning to Oskaloosa.
The earliest architectural Frank Wetherell commission known in Oskaloosa is the renovation of the N.B.
Frank Wetherell founded the second oldest architectural firm in the state in Des Moines, Iowa, in 1905.
Wetherell was prominent statewide as an architect known for public buildings, residences, and urban planning.
[3] He was a parishioner of St. James Episcopal Church (Oskaloosa, Iowa), which he designed in Gothic Revival architecture style.