He played in Major League Baseball (MLB) for the Texas Rangers, Toronto Blue Jays, New York Mets and Chicago White Sox.

On July 1, 2003, the White Sox acquired Carl Everett from the Texas Rangers in exchange for three players to be named later.

On July 25, 2003, Francisco, Josh Rupe, and minor leaguer Anthony Webster were sent to the Rangers to complete the trade.

On his first pitch as a Blue Jay, Francisco gave up a home run to the Yankees' Curtis Granderson.

[9] On June 23, 2012, after a save against the New York Yankees, Francisco was placed on the 15-day disabled list after feeling soreness in his oblique muscle.

On August 22, 2012, Francisco showed frustration by hurling a cooler in the dugout after giving up two runs in the top of the ninth inning.

[10] On May 30, 2013, Francisco was moved to the 60-day disabled list to make room on the 40-man roster for shortstop Omar Quintanilla.

On April 14, 2014, the White Sox signed Francisco to a minor league contract, and assigned him to the Triple-A Charlotte Knights.

[14] Francisco signed a minor league deal in late June with Toronto but was released on July 14, 2014, after not appearing in a game.