Francis Patrick "Frank" Gilhooley Sr. (June 10, 1892 – July 11, 1959) was an American outfielder in Major League Baseball, playing mostly as a right fielder from 1911 through 1919 for the St. Louis Cardinals (1911–12), New York Yankees (1913–18) and Boston Red Sox (1919).

Listed at 5 ft 8 in (1.73 m), 155 lb., Gilhooley batted left-handed and threw right-handed.

He was born in Toledo, Ohio, and attended Central Catholic High School there.

His most productive season came with the 1918 Yankees, when he appeared in a career-high 112 games while hitting .276 with 23 RBI, 59 runs and 19 extrabases, also career-numbers.

He married Mae Casey in 1917, and had 3 children, Mary Irene, Mary Frances and Frank Jr. Frank Jr. announced for the Toledo Mud Hens and was also the sports director at WTVG-TV, Channel 13, until 1986.