James Frank Gillespie (April 18, 1869 – November 26, 1954) was a U.S. Representative from Illinois.

He was admitted to the bar in 1892 and commenced practice in Charleston, West Virginia.

He moved to Bloomington, McLean County, Illinois, in 1894 and continued the practice of law.

He resumed the practice of law in Bloomington, Illinois, until his death there on November 26, 1954.

This article incorporates public domain material from the Biographical Directory of the United States Congress