[5] His grandfather started the House of LaRose, a beverage bottling and distribution company in Akron, Ohio, where Frank worked growing up.

He subsequently enlisted in the United States Army in 1998, serving in the 101st Airborne Division and later, the U.S. Special Forces as a green beret.

[7] He graduated from Ohio State University with a Bachelor of Science degree in consumer affairs and a minor in business administration.

LaRose had previously voted against governor John Kasich's nomination of Ohio Right to Life president Mike Gonidakis to the state medical board in 2012.

[13] LaRose voted for Senate Bill 5 which reduced collective bargaining rights for public workers (including police, firefighters and teachers).

[16][17] After the bill, which passed by a narrow margin, was repealed by a public referendum, LaRose said, "The voters have made it clear that this was not the course they wished to take.

"[14] LaRose sponsored Senate Bill 238, which removed the so-called "golden week" period where a voter was permitted to both register to vote and cast a ballot.

During the 2018 campaign, LaRose said he favored a different same-day registration system in states such as New Hampshire that take precautions against voter fraud.

[29] The Columbus Dispatch reported in 2022 that LaRose had "maintained a careful balance between champion of Ohio elections and skeptic of how other states conducted voting" since 2020.

[36] He was the "first Summit County resident elected Ohio secretary of state in about 166 years", according to Jim Simon, master of ceremonies of LaRose's swearing-in.

[42] In May, LaRose defended Ohio's congressional districts, opposed by Democrats for being gerrymandered to favor the Republican representatives in power.

[46] This increase in transparency led to finding various mistakes and recognizing thousands of voters who had been unduly marked as inactive by their respective counties.

"[48] That month, his office was reviewing Ohio voter registrations that might have been incorrectly deleted in vendor errors, with Democrats suing.

[50] In September 2019, he was released from a February 2019 lawsuit filed by members of environmental activist groups, who "accused elections officials of using unconstitutional tactics that kept certain initiatives from going before voters".

The plan also allowed for one secure drop box per county board of elections for voters to place their absentee ballots if they did not have time to mail them.

[59] On April 28, there were reports of long car lines outside county boards of elections as Ohioans who were not able to mail their absentee ballots the day before had to drop them off to make sure their vote counted.

"[64]  At a Lincoln Dinner in May 2023, LaRose told supporters the August election was "100% about keeping a radical pro-abortion amendment out of our constitution.

[70] At the beginning of his campaign, LaRose polled first in the 2024 Republican primary field over challengers State Senator Matt Dolan and businessman Bernie Moreno.

[73] In the following month, LaRose dismissed his press secretary Rob Nichols for posts on social media critical of Trump.

[74] On February 6, 2025, LaRose announced that he was running for Ohio State Auditor in 2026, seeking to succeed Keith Faber, who was term-limited.