Early in his career he specialized in the repertoire of Mozart and Rossini and later transitioned to the works of Puccini, Verdi, Donizetti and Bellini.
[2] Lopardo made his North American debut as Tamino in Die Zauberflöte with Opera Theater of St. Louis.
He entered into a long-standing relationship with The Metropolitan Opera in New York in 1989 in the role of Almaviva in Il barbiere di Siviglia.
He has sung as Edgardo, Rodolfo, the Duke, and Lenski in Eugene Onegin at the Opéra National de Paris.
[5] He was awarded an honorary doctorate from Queens College, Aaron Copland School of Music, in 1992, and in 2005 won a Grammy Award for Best Choral Performance for a recording of the Berlioz Requiem, performed with the Atlanta Symphony Orchestra and Chorus and conducted by Robert Spano.