Frank Clifford Wykoff (October 29, 1909 – January 1, 1980) was an American athlete, a triple gold medal winner in 4 × 100 m relay at the Olympic Games.

[1] Born in Des Moines, Iowa, Frank Wykoff has a place in track and field history by being the first man to ever win three Olympic relay gold medals, all in world record time.

Wykoff made his debut at the 1928 Summer Olympics in Amsterdam, where he finished fourth in the 100 m and ran an opening leg in the American 4 × 100 m relay team, which equaled the world record of 41.0 seconds in the final.

He was close to death the previous fall with a severe throat infection but recovered enough in the spring to tie the world record four times as a sprinter for Glendale.

At the 1932 Summer Olympics, Wykoff ran the anchor leg for the American 4 × 100 m relay team, which set a new world record of 40.0 seconds.