Zane was awarded a master's degree in experimental psychology from California State University, San Bernardino in 1992.

Zane's physique featured the second-thinnest waistline of all the Mr. Olympias (after Sergio Oliva), with his wide shoulders making for a distinctive V-taper.

He was given the nickname "The Chemist" due to his Bachelor of Science degree and, as he puts it: "Back in the day I took a lot of supplements and tons of amino acids.

Shortly before the competition he suffered a poolside accident in his home[13] and lost 15 pounds (6.8 kg) of muscle mass.

[14] Zane is one of only three men to have defeated Schwarzenegger (with Chester Yorton and Sergio Oliva) in a bodybuilding contest and one of the very few Mr. Olympia winners under 200 pounds (91 kg).

In 1985, Frank and his wife Christine owned and operated "Zane Haven" in Palm Springs, California where they conducted one-on-one sessions with clients who wished to possess a symmetrical physique.

[9] In 2005, Zane played the IFBB Announcer and worked as the consulting producer in the movie "See Arnold Run".

In 2011, Frank Zane appeared in the documentary Challenging Impossibility describing the weightlifting odyssey of spiritual teacher and peace advocate Sri Chinmoy.

[15] In June 2020, Frank Zane began filming a feature documentary on his life directed and produced by filmmaker Alex Ardenti.