Franciscus Hendrikus Gerardus "Frank" de Grave (born 27 June 1955) is a Dutch politician of the People's Party for Freedom and Democracy (VVD) and businessman.

De Grave served as acting Mayor of Amsterdam from 18 January 1994 until 1 June 1994 following the appointment of Ed van Thijn as Minister of the Interior in the Lubbers III cabinet.

De Grave was appointed as State Secretary for Social Affairs and Employment in the Kok I cabinet following the resignation of Robin Linschoten, taking office on 2 July 1996.

The cabinet resigned on 16 April 2002 following the conclusions of the NIOD report into the Srebrenica massacre during the Bosnian War and continued to serve in a demissionary capacity.

De Grave semi-retired from national politics and became active in the private sector and public sector and occupied numerous seats as a corporate director and nonprofit director on several boards of directors and supervisory boards (DSB Bank, DSM Company, Natura Artis Magistra, Verwey-Jonker Institute, Heart Foundation and the Public Pension Funds PFZW) and served on several state commissions and councils on behalf of the government (SEO Economic Research and the Social and Economic Council).