The Frankenstein–Dracula Variation is a chess opening for Black, usually considered a variation of the Vienna Game, beginning with the moves: or it can be reached by transposition from the Bishop's Opening: It involves many complications, but with accurate play is viable for both sides.

Jacob Øst-Hansen deployed it against John Nunn in Teesside 1972.

[1] Vasyl Ivanchuk used it against Viswanathan Anand in Roquebrune in 1992 in a game that ended in a draw.

Alexei Shirov played it as Black in a simultaneous exhibition in Canada 2011.

In 2019, Hikaru Nakamura played it in a rapid game in St. Louis against Jan-Krzysztof Duda.