Frankfurt Ostendstraße station is an underground S-Bahn station in central Frankfurt am Main, Germany.

It consists of two tracks, one each side of a central platform.

Its entrance escalators are located next to the Hanauer Landstraße.

The Seat of the European Central Bank is nearby.

The train station is served by S-Bahn lines S1, S2, S3, S4, S5, S6, S8 and S9.