Frankfurt (Main) Mühlberg station is an underground Rhine-Main S-Bahn station on the Frankfurt City Tunnel in the Frankfurt district of Sachsenhausen in the German state of Hesse.

It consists of two tracks on either side of an island platform.

The escalators down to the platform are located on Offenbacher Landstraße.

The station is served by S-Bahn lines S1, S2, S8, and S9.

This station is also served by Frankfurt city bus route 46, and night bus routes n62 and n63.