[citation needed] In 1948, after writing to several law firms and not hearing back from them, Muse decided to establish her own private practice.

On September 15, 1964, the Senate approved Freeman's nomination and she was officially appointed as the first black woman on the civil rights commission.

Freeman was subsequently reappointed by presidents Richard Nixon, Gerald Ford and Jimmy Carter, and held the position until July 1979.

In 1982, Freeman joined 15 other former high federal officials who formed a bipartisan Citizens Commission on Civil Rights, a group committed to ending racial discrimination and devising remedies that would counteract its harmful effects.

Sister Freeman had the honor of having a statue erected in downtown St. Louis in Kiener Plaza, at 500 Chestnut Street, with an unveiling date of November 21, 2017.

The honor was presented by the NAACP and had many patrons to include Washington Tabernacle Missionary Baptist Church where Sister Freeman was an active member.