He has previously played in Major League Baseball (MLB) for the San Diego Padres, Cleveland Indians / Guardians, Chicago Cubs, and Kansas City Royals.

[1] He made his professional debut in 2012 with the Dominican Summer League Padres and spent the whole season there, batting .267/.360/.416 with four home runs and 37 RBIs in 67 games.

[5] Reyes made his Major League debut on May 14, 2018, against the Colorado Rockies, getting the start in right field[6] after outfielders Wil Myers and Hunter Renfroe had both been placed on the injured list.

[11] After this fourth promotion, Reyes improved his approach at the plate[12] and raised his average from .221 to .280 through the end of the season while making regular starts in right field.

[21] On August 23, Reyes made an appearance as a pitcher against the St. Louis Cardinals, and recorded his first career pitching strikeout against Paul DeJong.

[26] He hit .186/.231/.288 with 2 home runs and 7 RBI in 19 games for Kansas City before he was optioned to the Triple-A Omaha Storm Chasers.

After spending time on the injured list with an undisclosed injury, Reyes was activated on August 11 and released by the Nationals.

[31] On January 8, 2024, Reyes signed a one-year contract with the Hokkaido Nippon-Ham Fighters of Nippon Professional Baseball.