He originated the roles of Inspector Kemp and The Blind Hermit in the Broadway musical Young Frankenstein (2007).
Renaud in La Cage aux Folles (2010),[5] Max Bialystock in The Producers (replacement, 2003; in the West End production in 2005[6]) and as Franz Leibkind in the first national tour.
[3] Applegate appeared Off-Broadway at Lincoln Center's Mitzi Newhouse Theater in the musical Happiness in 2009, directed and choreographed by Susan Stroman.
[14] Applegate's voice can be recognized as the narrator of documentaries for PBS, National Geographic, Disney, Bravo, and A&E.
He has guest starred in over 150 episodes of television including Seinfeld, Cosby, Growing Pains, FM, Malcolm in the Middle, ER, Murphy Brown, Newhart, Will & Grace and many others.