Born in Amsterdam, Netherlands, Eisenberger emigrated with his family to Canada when he was eight years old, entering through the iconic LIUNA Station as many immigrants did during that era.

He registered, but withdrew from the 2003 mayoral election, due to a ruled conflict of interest by the federal ethics counsellor stemming from the fact that Eisenberger was serving as chair of the Hamilton Port Authority.

[5] One of the key planks of his platform was a proposal to hire an independent integrity officer to help restore public trust in city hall, following the controversy around Larry Di Ianni's campaign contributions in 2003.

He sought and won support for this initiative which involved hiring new staff and developing a marketing campaign to help promote Hamilton.

[9] Another major initiative was the creation of the Jobs Prosperity Collaborative, a group of community leaders to help steer Hamilton's economic development.

[citation needed] After several years of debate, Eisenberger worked with both the provincial and federal governments to gather financial support ($60 million in total) to assist with efforts to clean up Randle Reef in Hamilton Harbour, a toxic hotspot from the city's industrial past.

Eisenberger was a founding board member for the provincial transportation agency, the Greater Toronto Transit Authority (GTTA) which later became Metrolinx.

[17] As part of Metrolinx, Eisenberger helped to initiate service improvements to the city's two rapid transit corridors, the north-south A-Line and the east-west B-Line,[18] and was a key force in the establishment of the West Harbour GO Transit rail station on James Street North that was meant to boost inter-regional connections between Hamilton, the Greater Toronto Area and the Niagara Region[19] The Province of Ontario established a new Metrolinx Board of Directors in 2009 at which time Eisenberger and all elected representatives, were removed from the board.

[20] Since winning the 2006 election, Eisenberger has pursued policies that he describes as "bringing ethics and integrity back to Hamilton council".