He was signed by the Chicago Bears of the National Football League (NFL) as an undrafted free agent in 2010.

During his senior season, in established numerous receiving records, was named a 2009 College Football All-American and was one of three 2009 Fred Biletnikoff Award finalists.

Barnes attended Homewood-Flossmoor High School in Flossmoor, Illinois, where he earned three letters for the Vikings playing quarterback.

It turned out to be enough time for the Vandals to answer on their final drive, and they converted a two-point conversion for the win.

[7] Barnes established both new Football Bowl Subdivision and All Division single-season reception records by surpassing Manny Hazard and Nick Smart, respectively.

Barnes was also discussed as a dark horse candidate for the 2009 Heisman Trophy, despite being on a BCS non-AQ conference team and not being a quarterback, based on thirty more catches than any other receiver and being close to the top in touchdowns.

"[15] At the 2010 East-West Shrine Game practice, Barnes "impressed scouts with the ability to consistently separate from defensive backs and find the openings in the coverage," according to Sports Illustrated's Tony Pauline.

[19] Barnes was also a member of the Arena Football Team Chicago Rush, having signed a contract on October 8, 2010.