He is best known for his many seasons with seven Major League Baseball (MLB) franchises, including the Seattle Mariners, Chicago White Sox, and New York Yankees.

On June 27, 2004, García and Ben Davis were traded to the Chicago White Sox in exchange for Michael Morse, Miguel Olivo, and Jeremy Reed.

García was the starting pitcher in Game 4 of the 2005 World Series for the Chicago White Sox, pitching seven scoreless innings against the Houston Astros.

García experienced a bit of controversy at the beginning of the 2006 season when he tested positive for marijuana during the World Baseball Classic.

In December 2006, García was traded to the Philadelphia Phillies for prospects Gavin Floyd and Gio González.

In his Tigers debut in late September, García, with a limited pitch count, threw 5 scoreless innings to get the win.

In his first game back with the White Sox, García went 4.1 IP allowing 5 ER in a losing effort.

On January 31, 2011, García agreed to a minor league contract with the New York Yankees worth $1.5 million.

García was on the mound in relief as the Sox won their second game of the season on April 10, as well as 2 other losses on May 15 and June 7.

[16][17] In 2012, García was expected to challenge for a starting spot with Phil Hughes, A. J. Burnett, Andy Pettitte and Michael Pineda.

However, Burnett was traded in the offseason, and Pineda was diagnosed with a shoulder injury, thereby allowing García into the rotation.

[18] García began the 2012 season with bad footing as he threw 5 wild pitches in his first start against the Baltimore Orioles.

[24] He was promptly signed to a minor league contract by the Baltimore Orioles,[25] and assigned to the Triple-A Norfolk Tides.

Although the Braves lost to the Los Angeles Dodgers, Garcia pitched well, giving up 2 runs over 6 innings and was in line for the win when he left the game.

[30] On April 18, 2014, García signed with the EDA Rhinos of the Chinese Professional Baseball League (CPBL).

[37] He appeared in four games and made one start for Oklahoma City, allowing seven runs in 7.1 innings and was released on April 21.

He spent the rest of 2015 with Aragua, where he won a league championship,[40] and started the first and final games of the 2016 Caribbean Series.

On April 8, 2016, Garcia came out of retirement and signed with the Sultanes de Monterrey of the Mexican Baseball League.