Her early infancy was largely spent in the affluent hunt country of Somerset County, New Jersey, with a brief interlude in Greece and Italy during her mother's short-lived second marriage to a US State Department official, Horace Fuller.

With the help of a graduation gift from her grandfather, she spent a gap year studying and working in Paris before getting a job as a salesgirl in the stationery department of Tiffany's, New York City.

In 1971, the Met allowed her to moonlight in San Francisco and in Santa Fe as Sesto and Cherubino respectively, but in 1972, hungry for more challenging roles, she decided to embark on a career as a freelance.

Her recording of Joseph Haydn's Harmoniemesse (taped under Leonard Bernstein in 1973) was the first item in what grew to be a large and eclectic discography, and a telecast of Le nozze di Figaro from Glyndebourne in 1973 launched her on a television career that eventually made her a familiar face on screens in America and across the world.

The highlights of her performing life included singing in Washington DC for Presidents Nixon, Carter, Reagan and George H. W. Bush, starring in a gala staged in honour of the 1992 Winter Olympics and participating in a televised concert led by Leonard Slatkin to mourn those murdered in the terrorist attacks of 9/11.

With a coltish physique and a warm, soft-grained, lyric mezzo-soprano voice that extended into soprano territory, she was a celebrated exponent of travesti roles like Hänsel, Idamante, and Octavian, and—aided by her striking beauty—she was also much admired playing leading ladies like Angelina, Charlotte, Dorabella, Lucette, Mélisande, Penelope and Zerlina.

These also featured prominently in her enormous recital repertoire, alongside Britten, Fauré, Handel, Offenbach, Poulenc, Schoenberg, Schubert, Schumann, Richard Strauss and the many American composers for whom she was an evangelist and, in several cases, a muse.

The main beneficiary of her philanthropy has been the Young Musicians Choral Orchestra, an East Bay organization that provides children from low income families with musical tuition, academic reinforcement and assistance in their personal development in order to help them to win a place at university.

Von Stade's many leisure activities include cooking, gardening, golf, sailing and ministering to a "West Highland terrorist" called Sadie.