Frederick is home to three dairies, a 1400-acre industrial park, and Frederick Regional Airport, which includes restored World War II hangars which house the World War II Airborne Demonstration Team.

[5] Originally established in 1901, the Frederick area was among the last of the Oklahoma Territory land to be opened to settlement.

[a] In 1902 the towns combined in order to take advantage of the Blackwell, Enid and Southern Railroad.

In the spring of 1905, President Teddy Roosevelt visited Frederick to meet with Jack "Catch-'em-alive" Abernathy, the famed barehanded wolf hunter, and introduced the area to tourism and its recreational value.

[7] [8] The Frederick Army Air Field opened in 1941, training pilots to fly UC-78 light transport aircraft and B-25 bombers.

[6][7] In 1962 a flagpole was erected in Pioneer Park, fulfilling the agreement between Gosnell, Hazel and the railroad.

The current City Manager is Kyle Davis and the Mayor is Kevin Ouellette, Sr.[7] Great Plains Technology Center is located in Frederick.

The following are NRHP-listed sites in Frederick: The Ramona Theatre, built in 1929, is an excellent example of Spanish Colonial style.

Interior details include electric twinkling stars and brenograph rolling clouds traveling across a midnight blue plaster sky.

The north side has an unusual curved wall, and is an outstanding example of the architects’ blending of classical styles.

[6] The Frederick Public Library, originally funded in 1915 by the Carnegie Foundation, is still in service.

[6] A life-size statue of Louis and Temple Abernathy on the Tillman County Courthouse Square honors two Frederick boys who, in 1910, became national celebrities at age 6 and 10 when they rode alone by horseback from Frederick to Washington, DC to visit President Taft, and on to New York City where they greeted former President Theodore Roosevelt on his return from an African safari.