Together with Kurt Tucholsky, Klabund, Walter Mehring, Mischa Spoliansky and Joachim Ringelnatz he worked in venues like Reinhardt's Schall und Rauch ensemble at the Großes Schauspielhaus or the Wilde Bühne led by Trude Hesterberg at the Theater des Westens in Charlottenburg, where he established the Tingel-Tangel-Theater cabaret in 1931.
Hollaender had his breakthrough when he wrote the film score for The Blue Angel (1930), including the most popular song "Falling in Love Again (Can't Help It)", performed by Marlene Dietrich.
He emigrated to the United States the next year, where he wrote the music for over a hundred films, including Destry Rides Again (1939), A Foreign Affair (1948), The 5,000 Fingers of Dr. T (1953 Academy Award nomination) and Sabrina (1954).
As "Frederick Hollander", he also wrote the semi-autobiographical novel Those Torn From Earth, released in 1941, which details the flight from Germany that many Jewish members of the film industry embarked on after the Nazis came to power and instituted the Nuremberg Laws.
Friedrich Hollaender: ...Ich bin von Kopf bis Fuss auf Musik eingestellt, 4 CDs with 20 pages Booklet, Membran Music Ltd., 2005; Distributed by Grosser und Stein GmbH, Pforzheim, ISBN 3-86562-044-2.