In the years 1613 and 1614, Frederick V made his Grand Tour to France, Great Britain and the Netherlands.

The Protestant Frederick V was deposed by Emperor Ferdinand II during the Thirty Years' War.

Without observing the obligatory year of mourning, Frederick married Eleonore of Solms-Laubach on 8 October 1627.

Anna Maria died on 25 May 1649 and the following year, on 20 May 1650, Frederick married his fifth and final wife, Elizabeth Eusebia of Fürstenberg.

They had following children: On 8 October 1627, Frederick V married his second wife, Countess Eleonore of Solms-Laubach (born: 9 September 1605; died: 6 July 1633), the daughter of Count Albert Otto Albrecht I of Solms-Laubach (1576-1610) and his wife, Landgravine Anna von Hesse-Darmstadt (1583-1631).

They had following children: On 21 January 1634, Frederick V married Countess Maria Elisabeth of Waldeck-Eisenberg (born: 2 September 1608; died: 19 February 1643), the daughter of Count Wolrad IV, Count of Waldeck-Eisenberg and his wife, Margravine Anna von Baden-Hachberg (1587-1649).

On 13 February 1644, Frederick V married his fourth wife, Baroness Anna Maria von Geroldseck und Sultz (born: 28 October 1593; died: 25 May 1649), the widow of the Count Frederick of Solms-Rödelheim and daughter of Baron Jacob Geroldseck und Sultz auf Hohengeroldseck (1565-1634) and his first wife, Baroness Barbara von Rappoltstein (1566-1621).