He sat on the family interest for County Durham from 1761 to 1774, and took an active part in debates over the British East India Company in 1773.
[1] He was returned as Member of Parliament for County Durham at the 1761 British general election on the family interest, where he replaced his younger brother Raby Vane.
He was favorable to the peace preliminaries in December 1762, but seconded the motion of his brother-in-law, Sir William Meredith, against the use of general warrants on John Wilkes and his followers in February 1764.
He rarely spoke in the House, but felt compelled in February 1771 to speak out against Meredith's unsuccessful but violent attempt to repeal a clause in the Nullum Tempus Act in the face of Administration.
[1] Vane's most active engagement with public business came in 1773, when he spoke in the House on the actions of the British East India Company and was appointed to the committee to investigate them.