Fredericka Douglass Sprague Perry (August 9, 1872 – October 23, 1943) was an American philanthropist and activist.

Perry founded the Colored Big Sister Home for Girls in 1934 in Kansas City, Missouri.

With her husband, John E. Perry, she worked to provide better health care to African-American children.

[5] She attended public school in Washington, DC, and then the Mechanics Institute in Rochester, New York.

[3] In 1906, she moved to Jefferson City, Missouri, where she taught home economics at Lincoln University.