Her father was employed as a löpare, munskänk and taffeltäckare at the royal court, and had earlier been a footman of Lovisa Meijerfeldt.

Fredrica Löf and her sisters was early on, under the name the "Löven girls", known to be a part of the "more refined Stockholm demimonde" or high class prostitutes.

Fredrica Löf had her first child, out of wedlock, in 1779, and the year after she is registered as living alone in her own residence with her daughter Johanna Fredrika.

Likely from about 1780, Fredrica Löf was educated as a student in the French Theatre at Bollhuset in Stockholm under Jacques Marie Boutet de Monvel.

Marianne Ehrenström compared her with Marguerite Georges,[2] and she was famed for "her well-sounding vocal organ as well as for her beautious Grecian-shaped face and her well-shaped figure, by which she, alongside much natural warmth in her play, enruptured her audience without effort"[2] Her way of acting was described as "noble", with a sense of feeling and soul suitable for "tenderness, nobility and fierté"; her voice was described as clear and soft.

[2] Gustav Mauritz Armfelt, in his capacity of a member of the Royal Swedish Academy of Art, who supervised the theatre, wrote to the monarch in 1788 and asked if someone else could perform the part of Siri Brahe, and recommended the actress Gertrud Elisabeth Forsselius instead of Fredrika Löf.

Among her parts were the title role in "Semiramis" by Voltaire, where she was admired for her "majestic" interpretation;[2] the title roles in "Athalie" by Racine and "Drottning Christina" (1790) by Gustav III, as Mrs Ferval in "Den förtroliga aftonmåltiden" and as Susanna in "The Marriage of Figaro" by Beaumarchais (1799).

On 30 June 1791, she played the role of Amalia in "Den okände eller världsförakt och ånger" ("The stranger or Worldcontempt and anxiety") by August von Kotzebue, which was a great success for her.

She was said to have performed the part with "a sensitivity beyond limits" which made "everyone cry", even the actresses from the French Theatre, who did not understand the language.

Her daughter, Jeanette Fredrique Fredrisen (1779–1854) married the opera singer Carl Magnus Craelius, singing master and teacher of Jenny Lind, and Fredrika Theresia Fredrisen (1780–1864) married major Anders Andersson (1767–1818) and the superintendent Jonas Peter Rundlöf (1787–1861).

At the time of her death, Fredrica Löf lived at the farm of her brother-in-law, Sörby, in Torsåker in Södermanland.