In 1793, under Captain Vence, she escorted an important convoy to the Levant, and then escaped a watching Anglo-Spanish squadron.

On 22 November 1802, she departed Toulon, bound to Saint-Domingue under Commodore Quérangal,[1] along with Guerrière and Duguay-Trouin.

The flotilla found itself caught in the Blockade of Saint-Domingue by the British ships Elephant, Bellerophon, Theseus, Vanguard, and Tartar.

Guerrière and Duguay-Trouin managed to escape, and Duquesne, separated from the squadron, attempted to flee in the night.

She was discovered by Tartar and Vanguard the next afternoon, and after a short artillery duel, Duquesne, outnumbered by her opponents, struck her colours.