[2] Fresh frozen plasma is made up of a complex mixture of water, proteins, carbohydrates, fats, and vitamins.

These generally are limited to the treatment of deficiencies of coagulation proteins for which specific factor concentrates are unavailable or undesirable.

That is, FFP is not used in people to reverse warfarin if there is no bleeding, even for an INR > 9 unless they need urgent surgery.

[10] Prophylactic plasma transfusions might have an effect for people with a blood clotting disorder and receive an invasive procedure.

Furthermore, different triggers for fresh frozen plasma may reduce the number of individuals requiring a transfusion within 7 days.

[citation needed] This trend may be attributable to multiple factors, possibly including decreased availability of whole blood due to widespread acceptance of the concept of component therapy.

[citation needed] Safe and effective alternative treatment often exists so that FFP is no longer the therapy of choice in many conditions.

Crystalloid or colloid solutions such as human serum albumin or plasma protein fraction, are preferable to FFP for volume replacement.

[citation needed] The most important alternative to the use of FFP is a comprehensive program of blood conservation.

This includes measures such as intraoperative cell salvage[10] and the realization that in many patients normovolemic anemia is not an indication for transfusion.