The Friedberg–Hanau railway is a 32.2 km long double-track, electrified mainline in the German state of Hesse.

The line has the timetable number of 633 and it is integrated in the Rhein-Main-Verkehrsverbund (Rhine Main Transport Association) as Regionalbahn service RB 49.

The line is used as a detour during operational failures that occasionally occur due to the high utilisation of the Main–Weser Railway between Frankfurt and Friedberg or during construction work.

In passenger transport, the line was formerly served by the Regionalbahn trains of the Hessische Landesbahn (HLB), using GTW 2/6 rolling stock.

Since December 2011, DB Regio Hessen has had the concession to operate services on the line with Bombardier Talent 2 electric multiple units.