His first important work was the construction of the town hall in Fürth[1] (1840–50) which is influenced by the Palazzo Vecchio in Florence.

Bürklein created also the Hauptbahnhof in Munich (1847–1849) with its steel construction and the stations of Augsburg, Bamberg, Ansbach, Neu-Ulm, Hof, Nördlingen, Rosenheim, Würzburg, Nuremberg and Bad Kissingen.

From 1851 Bürklein was the chief architect of the royal Maximilianstraße in Munich with all its state buildings including the Maximilianeum.

Its Neo-Gothic architecture was influenced by the Perpendicular style and was strongly disputed.

In June 2015, the Bavarian Parliament named the entrance hall of the Maximilianeum after Friedrich Bürklein.